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Capecitabine
Key Details About Capecitabine
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- Uses:Â Used for metastatic colorectal, gastric, and breast cancers, often in combination with other treatments like docetaxel.
- Administration:Â Taken orally as a tablet, usually twice daily within 30 minutes of a meal, typically in 3-week cycles (2 weeks on, 1 week off).
- Common Side Effects:
 Hand-foot syndrome (redness, pain, peeling on palms/soles), diarrhea, vomiting, fatigue, and stomatitis.
- Mechanism of Action: A nucleoside metabolic inhibitor (antimetabolite) that, after conversion, interferes with RNA and DNA synthesis, hindering cancer cell growth.
- Drug Interactions:Â Significant interactions with the blood thinner warfarin, which can increase the risk of serious bleeding.
Description
Capecitabine (brand name Xeloda) is an oral chemotherapy medication used to treat metastatic breast, colorectal, and gastric cancers. It acts as a prodrug, converting into active 5-fluorouracil (5-FU) inside tumor cells to inhibit DNA synthesis. Common side effects include hand-foot syndrome, diarrhea, nausea, and low blood cell counts.Â



